National Library of Medicine - Small Business
Department Of Health And Human Services, National Institutes Of Health
The National Library of Medicine (NLM) supports small business innovation in biomedical informatics—a multidisciplinary field that combines biomedical research with data science, informatics, and information technology. The program aims to encourage small businesses to develop novel technologies, tools, and platforms that can enhance health care delivery, biomedical research, data management, and health information dissemination.
Jargon-free version
Helps small businesses create innovative products in biomedical informatics and health data science. Provides funding to support their development efforts.
Quick Facts
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What Is This Program?
What Benefits Are Offered?
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📋What Are the Application Steps & Timeline?
- 📝Steps to Apply
- Review the NIH Grants Process Overview
- Prepare the application using NIH Application Forms and Instructions
- Submit the application via the designated method
- 🌐Application Portal
- https://www.nlm.nih.gov/ep/grants_resources.html
- 📤Submission Method
- online
- 🔄Intake Type
- rolling
📄What Documents Are Required?
- ✅Required Documents
- Face page (PHS 398, Form Page 1)
- Updated Project Summary page (PHS 398, Form Page 2)
- Budget pages (PHS 398, Form Page 4 and Form Page 5)
- Budget Justification
- Biographical sketches
- New Resources Page(s) (PHS 398, Resources Format Page)
- New Checklist (PHS 398, Checklist Format Page)
- K99 Final Progress report (PHS 398 Continuation Format Page)
- Final evaluation statement by the K99 phase mentor
- Updated research plan (PHS 398 Continuation Format Page)
- Human Subjects section with IRB approval
- Vertebrate Animals section with IACUC approval
- Current Other Support page for the R00 candidate
- Institutional commitment letter
- 📐Format Requirements
- Use PHS398 Form Pages and combine into a single .pdf file.
- ✉️Supporting Letters
- Institutional commitment letter must describe its commitment to the candidate and the PI’s career development.
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💰What Expenses Are Eligible?
- 🧾Eligible Expenses
- salary
- fringe benefits
- research costs
- facilities & administrative costs
- 🚫Ineligible Expenses
- startup package
- usual institutional commitment to provide salary for tenure-track professors
- 📏Expense Caps
- The total cost for the independent phase (R00) may not exceed $249,000 per year.
- 💳Payment Model
- reimbursement
- ⏪Retroactive Expenses Eligible
- No
🤝Is Matching Funding Required?
- 🔀Matching Required
- Yes
- 📊Matching Ratio
- 25% minimum
- 🏦Eligible Matching Sources
- cash
- in-kind
- 📚Stacking Rules
- Allowed
- 🛡️Proof of Matching Required
- Institutional commitment letter
📊What Are the Reporting Requirements?
- 🗓️Reporting Frequency
- annual
- 📑Reporting Requirements
- Final FFR
- K99 Final Progress report
- 🔍Audit Requirements
- OMB Uniform Guidance Single Audit if the recipient expends $750,000 or more in federal awards
- 📢Branding Requirements
- Acknowledgment of federal funding is required
- 🗄️Record Retention Period
- 3 years post-final-report
How Do I Apply?
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FAQFrequently Asked Questions
Visit the program page for detailed eligibility requirements.
This program offers funding up to $2,975,321 (minimum $2,211,241).
This program accepts applications on a rolling basis.
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