National Center for Advancing Translational Sciences - Small Business
Department Of Health And Human Services, National Institutes Of Health
The National Center for Advancing Translational Sciences' (NCATS') mission is to turn research observations into health solutions through translational science. We work to develop or enhance the development, testing, and implementation of diagnostics and therapeutics for a wide range of diseases and conditions. Key approaches include understanding what’s similar across diseases to spur multiple treatments at a time, developing models that better predict a person’s reaction to treatment, enhancin
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Helps small businesses develop and sell new health technologies. Provides funding and support for research and commercialization efforts.
Quick Facts
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What Is This Program?
What Benefits Are Offered?
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📋What Are the Application Steps & Timeline?
- 📝Steps to Apply
- Identify eligibility for SBIR/STTR programs
- Prepare grant application according to guidelines
- Submit application through the designated portal
- Await peer review and funding decision
- 🌐Application Portal
- https://ncats.nih.gov/funding
- 📤Submission Method
- online
- 📅Key Dates
- 05/12/2026Posting Date for RFA-OD-27-00506/15/2028Expiration Date for RFA-OD-27-00505/11/2026Posting Date for RFA-OD-27-00406/15/2028Expiration Date for RFA-OD-27-004
- 🔄Intake Type
- periodic
📄What Documents Are Required?
- ✅Required Documents
- SF-424 (Application for Federal Assistance)
- SF-424A (Budget Information - Non-Construction)
- SF-424B (Assurances)
- Project Narrative
- Budget Narrative
- indirect cost rate agreement
- IRB approval letter
- environmental review
- 📐Format Requirements
- PDF only, max 10MB
- ✉️Supporting Letters
- Letters of support/reference may be required but not explicitly stated.
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💰What Expenses Are Eligible?
- 🧾Eligible Expenses
- research and development costs
- clinical technology development
- instruments and devices for clinical research
- 💳Payment Model
- mixed
🤝Is Matching Funding Required?
- 🔀Matching Required
- Yes
- 📊Matching Ratio
- 1:1
- 🏦Eligible Matching Sources
- cash
- in-kind contributions
- 📚Stacking Rules
- Allowed
- 🛡️Proof of Matching Required
- Documentation of cash or in-kind contributions
📊What Are the Reporting Requirements?
- 🗓️Reporting Frequency
- annual
- 📑Reporting Requirements
- SF-425 Federal Financial Report
- performance progress report
- 🔍Audit Requirements
- OMB Uniform Guidance Single Audit if the recipient expends $750,000 or more in federal awards.
- 📢Branding Requirements
- Acknowledgment of federal funding is required in all publications and presentations.
- 🗄️Record Retention Period
- 3 years post-final-report
How Do I Apply?
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FAQFrequently Asked Questions
Visit the program page for detailed eligibility requirements.
This program offers funding up to $1,301,338 (minimum $1,301,338).
This program accepts applications on a rolling basis.
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