National Center for Advancing Translational Sciences - Rare Diseases
Department Of Health And Human Services, National Institutes Of Health
The National Center for Advancing Translational Sciences' (NCATS') mission is to turn research observations into health solutions through translational science. We work to develop or enhance the development, testing, and implementation of diagnostics and therapeutics for a wide range of diseases and conditions. Key approaches include understanding what’s similar across diseases to spur multiple treatments at a time, developing models that better predict a person’s reaction to treatment, enhancin
Jargon-free version
Helps researchers develop new treatments for rare diseases and supports innovative clinical trials. Provides resources and collaboration opportunities for advancing health solutions.
Quick Facts
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What Is This Program?
What Benefits Are Offered?
Funding and support for research, development, and commercialization of new translational technologies and health solutions, including specific programs for rare diseases, scientific conferences, and career development. Also offers technical assistance, training, and resources.
Who Is Eligible?
Business Size: small
Industries: translational science, clinical technology, instruments, devices, preclinical drug discovery and development, biomedical research informatics, clinical research, health research informatics, dissemination research, implementation research, rare disease research
Region: United States
Other Criteria: research organizations, early-stage companies, investigators, researchers, companies engaging in research and development with commercialization potential, focus on public health relevance, diverse group of people (for challenges), patients and advocates (for resources)
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Browse Partner Directory🏆 Detailed Application Guide
📋What Are the Application Steps & Timeline?
- 📝Steps to Apply
- Identify funding opportunity
- Prepare application materials
- Submit application through the portal
- Await peer review results
- Receive funding decision
- 🌐Application Portal
- https://ncats.nih.gov/funding/opportunities
- 📤Submission Method
- online
- 📅Key Dates
- 05/12/2026Posting Date for RFA-OD-27-00506/15/2028Expiration Date for RFA-OD-27-00505/11/2026Posting Date for RFA-OD-27-00406/15/2028Expiration Date for RFA-OD-27-004
- 🔄Intake Type
- fixed-deadline
📄What Documents Are Required?
- ✅Required Documents
- SF-424 (Application for Federal Assistance)
- SF-424A (Budget Information - Non-Construction)
- SF-424B (Assurances)
- Project Narrative
- Budget Narrative
- Indirect cost rate agreement
- IRB approval letter
- Environmental review
- 📐Format Requirements
- PDF only, max 10MB
- ✉️Supporting Letters
- Letters of support/reference are required.
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💰What Expenses Are Eligible?
- 🧾Eligible Expenses
- research activities
- clinical trials
- development of health solutions
🤝Is Matching Funding Required?
📊What Are the Reporting Requirements?
- 🔍Audit Requirements
- OMB Uniform Guidance Single Audit if the recipient expends $750,000 or more in federal awards in a fiscal year
- 🗄️Record Retention Period
- 3 years post-final-report
How Do I Apply?
Know a grant consultant who should be listed here? Refer them.
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FAQFrequently Asked Questions
This program is available to small businesses in translational science, clinical technology, instruments industries located in United States.
Contact the program administrator for funding details.
This program accepts applications on a rolling basis.
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5 columns per program
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- Program title and CFDA number
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- Short program description
- 2,812 active US federal assistance listings
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24 columns per program
Grant consultants, nonprofit grant writers, proposal teams
- Everything in Basic, plus 23 more columns
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- Aggregation tabs: By Organization, By Theme, By Audience, Deadlines
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49 columns per program
Data teams, AI builders, large grant operations, due-diligence research
- Everything in Pro, plus 25 more deep-extracted columns
- Long-form description + ideal-applicant summary + success tips
- Application steps, required documents, NOFO URLs, key dates
- Eligible / ineligible expenses, expense caps, payment model
- Matching ratios, eligible sources, stacking rules
- Reporting frequency, requirements, single-audit thresholds
- Plain-English 1-2 sentence rewrite of every program
- Contact Directory tab — outreach-ready contact list
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