21st Century Cures Act: Regenerative Medicine Initiative - Research Projects
Department Of Health And Human Services, National Institutes Of Health
The Regenerative Medicine Innovation Project (RMIP) was established by the 21st Century Cures Act to accelerate progress in the field by supporting clinical research on adult stem cells, while promoting scientific rigor and protecting patient safety. This initiative is a trans-NIH effort, in coordination with the Food and Drug Administration (FDA). Regenerative medicine is an emerging area of science that holds great promise for treating and even curing a variety of injuries and diseases. Rege
Jargon-free version
Helps researchers develop new treatments using adult stem cells. Provides funding for clinical research projects in regenerative medicine.
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What Is This Program?
What Benefits Are Offered?
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📋What Are the Application Steps & Timeline?
- 📝Steps to Apply
- Submit a research proposal
- Provide representative samples of source stem cells
- Complete application forms as required
- 🌐Application Portal
- https://www.nih.gov/regenerative-medicine-innovation-project-rmip/funding-opportunities
- 📤Submission Method
- online
- 📅Key Dates
- September 21, 2025Earliest Submission DateOctober 22, 2025Application Due Date
- 🔄Intake Type
- fixed-deadline
📄What Documents Are Required?
- ✅Required Documents
- SF-424 (Application for Federal Assistance)
- SF-424A (Budget Information - Non-Construction)
- SF-424B (Assurances)
- Project Narrative
- Budget Narrative
- indirect cost rate agreement
- IRB approval letter
- environmental review
- 📐Format Requirements
- PDF only, max 10MB
- ✉️Supporting Letters
- Letters of support/reference are required.
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💰What Expenses Are Eligible?
- 🧾Eligible Expenses
- clinical research on adult stem cells
- characterization of source stem cells
- clinical-grade stem cell products
- 💳Payment Model
- mixed
🤝Is Matching Funding Required?
- 🔀Matching Required
- Yes
- 📊Matching Ratio
- 25% minimum
- 🏦Eligible Matching Sources
- cash
- in-kind contributions
- 📚Stacking Rules
- Allowed
- 🛡️Proof of Matching Required
- Documentation of matching funds is required
📊What Are the Reporting Requirements?
- 🗓️Reporting Frequency
- annual
- 📑Reporting Requirements
- performance progress report
- SF-425 Federal Financial Report
- 🔍Audit Requirements
- OMB Uniform Guidance Single Audit if the recipient expends $750,000 or more in federal awards
- 📢Branding Requirements
- acknowledgment of federal funding
- 🗄️Record Retention Period
- 3 years post-final-report
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FAQFrequently Asked Questions
Visit the program page for detailed eligibility requirements.
This program offers funding up to $6,144,154 (minimum $913,996).
This program accepts applications on a rolling basis.
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